Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

The sublime evokes our awe, our terror, and our wonder. Applied first in ancient Greece to the heights of literary expression, in the 18th-century the sublime was extended to nature and to the sciences, enterprises that viewed the natural world as a manifestation of God's goodness, power, and wisdom. In The Scientific Sublime, Alan Gross reveals the modern-day sublime in popular science. He shows how the great popular scientists of our time--Richard Feynman, Stephen Hawking, Steven Weinberg, Brian Greene, Lisa (...) Randall, Rachel Carson, Stephen Jay Gould, Steven Pinker, Richard Dawkins, and E. O. Wilson--evoke the sublime in response to fundamental questions: How did the universe begin? How did life? How did language? These authors maintain a tradition initiated by Joseph Addison, Edmund Burke, Immanuel Kant, and Adam Smith, towering 18th-century figures who adapted the literary sublime first to nature, then to science--though with one crucial difference: religion has been replaced wholly by science. In a final chapter, Gross explores science's attack on religion, an assault that attempts to sweep permanently under the rug two questions science cannot answer: What is the meaning of life? What is the meaning of the good life? (shrink)

Emotion regulation strategies may reduce the negative relationship between math anxiety and mathematics accuracy, but different strategies may differ in their effectiveness. We recorded electrodermal activity to examine the effect of physiological arousal on performance during different applied ER strategies. We explored how ER strategies might affect the decreases in accuracy attributed to physiological arousal in high math anxious individuals. Participants were instructed to use cognitive reappraisal, expressive suppression, or a “business as usual” strategy. During the ES condition, HMA individuals (...) showed decreases in math accuracy associated with increased EDA, compared to low math anxious individuals. For both HMA and LMA groups, CR reduced the association between physiological arousal and math accuracy, such that even elevated physiological arousal levels no longer had a negative association with math accuracy. These results show that CR provides a promising technique for ameliorating the negative relationship between math anxiety and math accuracy. (shrink)

Socrates' aim in the Republic is to show that being just is crucial for happiness. In Republic IV, Socrates argues that the just individual is one in whom each part of the soul or psyche performs its proper function, with the result that the individual attains psychic harmony. Commentators have worried, however, that this account of what it is to be just has little to do with being just in the ordinary sense of the term, which involves acting with regard (...) for the good of others. In this essay, I describe three attempts to show that there is a connection between Socrates' account of justice and justice in the ordinary sense of the term and I raise criticisms of each. I then outline my own approach, which emphasizes the importance of good relations with others for happiness. (shrink)

This book describes the development of the scientific article from its modest beginnings to the global phenomenon that it has become today. The authors focus on changes in the style, organization, and argumentative structure of scientific communication over time. This outstanding resource is the definitive study on the rhetoric of science.

De Neys offers a welcome departure from the dual-process accounts that have dominated theorizing about reasoning. However, we see little justification for retaining the distinction between intuition and deliberation. Instead, reasoning can be treated as a case of multiple-cue decision making. Reasoning phenomena can then be explained by decision-making models that supply the processing details missing from De Neys's framework.

Accessing BRCA1/2 data facilitates the detection of disease-associated variants, which is critical to informing clinical management of risks. BRCA1/2 data sharing is complex and many practices exist. We describe current BRCA1/2 data-sharing practices, in the United States and globally, and discuss obstacles and incentives to sharing, based on 28 interviews with personnel at U.S. and non-U.S. clinical laboratories and databases. Our examination of the BRCA1/2 data-sharing landscape demonstrates strong support for and robust sharing of BRCA1/2 data around the world, increasing (...) global accesses to diverse data sets. (shrink)

Plato's Republic has proven to be of astounding influence and importance. Justly celebrated as Plato's central text, it brings together all of his prior works, unifying them into a comprehensive vision that is at once theological, philosophical, political and moral. The essays in this volume provide a picture of the most interesting aspects of the Republic, and address questions that continue to puzzle and provoke, such as: Does Plato succeed in his argument that the life of justice is the most (...) attractive one? Is his tripartite analysis of the soul coherent and plausible? Why does Plato seem to have to force his philosopher-guardians to rule when they know this is something that they ought to do? What is the point of the strange and complicated closing Myth of Er? This volume will be essential to those looking for thoughtful and detailed excursions into the problems posed by Plato's text and ideas. (shrink)

This study examines the public's and physicians' willingness to support deception of insurance companies in order to obtain necessary healthcare services and how this support varies based on perceptions of physicians' time pressures. Based on surveys of 700 prospective jurors and 1617 physicians, the public was more than twice as likely as physicians to sanction deception (26% versus 11%) and half as likely to believe that physicians have adequate time to appeal coverage decisions (22% versus 59%). The odds of public (...) support for deception compared to that of physicians rose from 2.48 to 4.64 after controlling for differences in time perception. These findings highlight the ethical challenge facing physicians and patients in balancing patient advocacy with honesty in the setting of limited societal resources. (shrink)

Delays in early language development are characteristic of young autistic children, and one of the most recognizable first concerns that motivate parents to seek a diagnostic evaluation for their child. Although early language abilities are one of the strongest predictors of long-term outcomes, there is still much to be understood about the role of language impairment in the heterogeneous phenotypic presentation of autism. Using a person-centered, Latent Profile Analysis, we first aimed to identify distinct patterns of language and social communication (...) ability in a clinic-based sample of 498 autistic children, ranging in age from 18 to 60 months. Next, a multinomial logistic regression analysis was implemented to examine sociodemographic and child-based developmental differences among the identified language and social communication profiles. Three clinically meaningful profiles were identified from parent-rated and clinician-administered measures: Profile 1 “Relatively Low Language and Social Communication Abilities,” Profile 2 “Relatively Elevated Language and Social Communication Abilities,” and Profile 3 “Informant Discrepant Language and Relatively Elevated Social Communication Abilities.” Overall, young autistic children from the lowest-resource households exhibited the lowest language and social communication abilities, and the lowest non-verbal problem-solving and fine-motor skills, along with more features of attention-deficit/hyperactivity disorder and atypical auditory processing. These findings highlight the need for effective community-based implementation strategies for young autistic children from low-resource households and underrepresented communities to improve access to individualized quality care. (shrink)

Alan Gross applies the principles of rhetoric to the interpretation of classical and contemporary scientific texts to show how they persuade both author and audience. This invigorating consideration of the ways in which scientists--from Copernicus to Darwin to Newton to James Watson--establish authority and convince one another and us of the truth they describe may very well lead to a remodeling of our understanding of science and its place in society.

Comatose survivors of cardiac arrest may die following withdrawal of life-sustaining therapy (WLST) due to poor neurologic prognosis. Family members, acting as surrogate decision makers, are frequently asked to decide whether the patient should continue to receive ongoing life-sustaining therapy such as mechanical ventilation in this context of risk of death following removal. Sometimes, physicians and family members disagree about what is in the patient's best interest, and this conflict causes distress for both families and medical personnel. This article examines (...) themes recorded in the medical records of 24 cardiac arrest patients at Columbia University Medical Center (CUMC) whose families chose to pursue continued life support despite physician recommendations for withdrawal. In documented conversations between patients' families and their providers, the most prominent themes included faith in miracles, the inappropriateness of "playing God," the value of more time with the patient, and differences in how providers and family members perceived the patient's status. (shrink)

In this review of the central tenets of hope theory, we examine the meta-theoretical, theoretical, and methodological foundations of the literature base. Our analysis moves from a broad examination of the research landscape in hope theory across disciplines, to a deeper investigation of the empirical literature in university students. This review highlights the significant impact of this body of research in advancing our understanding of aspects of thriving characterized by hope. However, we also evidence several limitations that may impede the (...) advancement of the next wave of growth in this field. To address these limitations, we argue for an interdisciplinary approach to expanding the meta-theoretical, theoretical, and methodological horizons, enabling a more dynamic systems approach to the study of hope. Drawing on the intersection of positive psychology with systems thinking, we describe a methodological approach that enables a deeper examination of the processes and interactions through which hope emerges, using an analysis of the lived experience of young people. It is proposed that this research agenda will bring to life an alternate story about the resourcefulness of our youth through their own voice, enabling us to leverage this in the design of more effective strategies to facilitate hope in the future. This research agenda provides a roadmap that will provide alternative methodologies that address the current limitations in the field of hope research and, importantly, can provide fuel to spur on the acceleration of the next wave of research and practice in the field of positive psychology more broadly. (shrink)

The following views were presented at the Annual Meeting of the American Association for the Advancement of Science Seminar “Teaching Ethics in Science and Engineering”, 10–11 February 1993 organized by Stephanie J. Bird , Penny J. Gilmer and Terrell W. Bynum . Opragen Publications thanks the AAAS, seminar organizers and authors for permission to publish extracts from the conference. The opinions expressed are those of the authors and do not reflect the opinions of AAAS or its Board of Directors.

Discussions of science and values in risk management have largely focused on how values enter into arguments about risks, that is, issues of acceptable risk. Instead this volume concentrates on how values enter into collecting, interpreting, communicating, and evaluating the evidence of risks, that is, issues of the acceptability of evidence of risk. By focusing on acceptable evidence, this volume avoids two barriers to progress. One barrier assumes that evidence of risk is largely a matter of objective scientific data and (...) therefore uncontroversial. The other assumes that evidence of risk, being "just" a matter of values, is not amenable to reasoned critique. Denying both extremes, this volume argues for a more constructive conclusion: understanding the interrelations of scientific and value issues enables a critical scrutiny of risk assessments and better public deliberation about social choices. The contributors, distinguished philosophers, policy analysts, and natural and social scientists, analyze environmental and medical controversies, and assumptions underlying views about risk assessment and the scientific and statistical models used in risk management. (shrink)

The COVID-19 outbreak has placed extraordinary demands upon healthcare systems worldwide. Italy's hospitals have been among the most severely overwhelmed, and as a result, Italian healthcare workers' well-being has been at risk. The aim of this study is to explore the relationships between dimensions of burnout and various psychological features among Italian healthcare workers during the COVID-19 emergency. A group of 267 HCWs from a hospital in the Lazio Region completed self-administered questionnaires online through Google Forms, including the Maslach Burnout (...) Inventory, Resilience Scale, and Intolerance of Uncertainty Scale Short Form. Cluster analysis highlighted two opposite burnout risk profiles: low burnout and high-risk burnout. The high-risk group had lower resilience and greater difficulties in tolerating the uncertainty than the low-burnout group. A set of general linear models confirmed that both IU subscales, prospective and inhibition, moderated the relationship between resilience and burnout. In conclusion, the results showed that individual levels of resilience and one's ability to tolerate uncertainty have been significant factors in determining the impact of the COVID-19 emergency on HCWs. The use of emotional strategies that allow individuals to stay in a critical situation without the need to control it appears to protect against burnout in these circumstances. (shrink)

This accessible book examines the philosophical foundations of Chaim Perelman's rhetorical theory. In addition to offering a brief biography, it explores Perelman's deep philosophical commitments and his concern for the ways in which the details of actual texts realize those commitments. The authors show that Perelman still reigns supreme when it comes to the elucidation of actual texts. His is a microanalysis of arguments, one that is endlessly suggestive of ways of analyzing texts at the level of the word and (...) phrase, the arrangement of parts, and the structure of arguments. Book jacket. (shrink)

Examines the nature of rhetorical theory and criticism, the rhetoric of science, and the impact of poststructuralism and postmodernism on contemporary accounts of rhetoric.

This volume offers a comprehensive guide to the extensive corpus of Jean-Luc Marion’s ideas, including a discussion of contemporary French phenomenology and critical appraisal of Marion’s ideas by leading scholars in the field. The contributors apply Marion’s thought to various fields of study, including theology, art, literature and psychology.

The ArgumentConflicts between scientists over credit for their discoveries are conflicts, not merely in, but of science because discovery is not a historical event, but a retrospective social judgment. There is no objective moment of discovery; rather, discovery is established by means of a hermeneutics, a way of reading scientific articles. The priority conflict between Roger Guillemin and Andrew Schally over the discovery of the brain hormone, TRF, serves as an example. The work of Robert Merton, Thomas Kuhn, Augustine Brannigan, (...) and Grygory Markus shows that scientists read scientific articles by means of the application of a set of pragmatic rules that subtend the normative requirements of what counts as a scientific discovery. In other words, there is a hermeneutics of science, but it is internal to that form of life. Recategorization of priority conflicts has an impact on our view of scientific controversy generally. The impact is the revision of the boundary lines of scientific controversy and the further specification of its fine-structure. (shrink)

In this collection edited by Alan G. Gross and Arthur E. Walzer, scholars in communication, rhetoric and composition, and philosophy seek to “reread” Aristotle’s Rhetoric from a purely rhetorical perspective.

This paper examines Ian Hacking's arguments in favor of entity realism. It shows that his examples from science do not support his realism. Furthermore, his proposed criterion of experimental use is neither sufficient nor necessary for conferring a privileged status on his preferred unobservables. Nonetheless his insight is genuine; it may be most profitably seen as part of a more general effort to create a space for a new form of scientific and philosophical certainty, one that does not require foundations.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.4 (2000) 319-335 [Access article in PDF] Rhetoric as a Technique and a Mode of Truth: Reflections on Chaïm Perelman Alan Gross In memoriam: Henry Johnstone, fons et origo.In one of his many criticisms of The New Rhetoric, the philosopher Henry W. Johnstone Jr. complains about its chapter "The Dissociation of Concepts" that "one is never sure whether [Chaïm Perelman is] thinking of rhetoric primarily (...) as a technique or primarily as a mode of truth. One wonders, too, what status [he is] claiming for the book itself" (1978, 99). 1 Since the chapter in question largely concerns philosophical argument, the doubt is very much apropos. But the response to Johnstone's implied question--a response that Johnstone does not think available--is that the correct answer legitimately varies in a systematic way. While in philosophical contexts, and, incidentally, in scientific ones, rhetoric is invariably a mode of truth, in contexts of public address it need not be. To see how this systematic variation might be the case, I will focus, as does Johnstone, on the dissociation of concepts as a test case of the robustness of a rhetoric oriented toward truth. To do so, I must first define dissociation and then come to terms with the way in which concepts are dissociated in public address, in philosophy, and in science. In treating these examples, however, I must be wary. While they will vary systematically according to field, they are not each instances of any general "law" of dissociation. Johnstone is surely right to "doubt whether there is any general logic of dissociation; there is only the logic of each particular dissociation, generated in each case by a particular problem" (99). When I have run through my examples, I can return to Johnstone's question about the status of rhetoric and of Perelman's study of it.Suppose that, in a campaign for the United States Senate, my opponent says that the central issue is high taxes, not the rise of medical costs, while I say that the central issue is medical costs, not high taxes. Neither of us [End Page 319] need be engaged in the dissociation of concepts; we may simply be excluding taxes and medical care, respectively, from political matters that deserve our immediate and full attention; we may simply be breaking the link between these issues and those of high political salience. In Perelman's words, "[T]he technique of breaking up a liaison consists... in asserting that elements that should remain separated and independent are improperly associated" (Perelman and Olbrechts-Tyteca 1969, 411). Yet, if we think that adequate medical care for all Americans is a moral issue, that it transcends politics, we are dissociating this issue from the category of campaign issues of the ordinary sort, those that deal "merely" with expediency. In the process, we are devaluing matters of mere expediency. Dissociation is a way of taking the argumentative high ground, of putting an issue on a different plane, an act that in this case turns a political race into a moral contest. In Perelman's words, "[T]he dissociation of notions brings about a more or less profound change in the conceptual data that are used as a basis of argument. It is then no more a question of breaking the links that join independent elements, but of modifying the very structure of these elements" (412).To illustrate this difference, I will use two parallel passages on the same topic: one from Stephen Douglas and the other from Abraham Lincoln, both from the debate between them in Alton, Illinois, on 15 October 1858. In his passage, Douglas stoutly defends states' rights: This government was made on the great basis of the sovereignty of the States--the right of each state to regulate its own domestic institutions to suit itself, and that right was conferred with the understanding and expectation that inasmuch as each locality had separate and distinct interests, each state must have different and distinct local and domestic institutions, corresponding to the wants... (shrink)

The embodied simulation of smiles involves motor activity that often changes the perceivers' own emotional experience (e.g., smiling can make us feel happy). Although Niedenthal et al. mention this possibility, the psychological processes by which embodiment changes emotions and their consequences for processing other emotions are not discussed in the target article's review. We argue that understanding the processes initiated by embodiment is important for a complete understanding of the effects of embodiment on emotion perception.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 34.4 (2001) 275-291 [Access article in PDF] The Conceptual Unity of Aristotle's Rhetoric 1 - [PDF] Alan G. Gross and Marcelo Dascal The standard view--that the Rhetoric lacks conceptual unity--has strong and prestigious support, stretching over most of the century. To David Ross in 1923 the unity of the Rhetoric was practical, not theoretical; to misunderstand this fact was to see this work, mistakenly, as (...) "a curious jumble of literary criticism with second-rate logic, ethics, and politics, and jurisprudence, mixed with the cunning of one who knows well how the weaknesses of the human heart are to be played upon" (285). So unaltered has been this view over the years that, in 1995, Jonathan Barnes could turn Ross's metaphor into an argument concerning the Rhetoric's lack of intellectual focus: it presents, not one art, but fragments of three arts, and of three arts that exist quite independently of rhetoric. The sections on logic have the closest connections with dialectic and in part overlap with what Aristotle says in the Topics; the sections on the emotions are linked to the ethical and psychological writings; Book III... shares its subject matter with the Poetics. Rhetoric... is a magpie, thieving a piece of one art and a piece of another, and then botching a nest of its own. (Companion 263-64) To Ross and Barnes, while logos, êthos, and pathos are essential to rhetorical invention, and style and arrangement are essential to rhetorical performance, they have nothing conceptually in common. Insofar as disciplinary identity depends on such conceptual unity, rhetorical studies lack such identity.William Grimaldi offers an alternate view; beneath Ross's jumble, he sees as the work's fundamental unifying principle, the enthymeme, which serves both as a form of argument and as a source for arguments about fact, character, and emotion. On this view, the factual content of a rhetorical argument is structured logically, a structure that is then molded linguistically [End Page 275] by means of êthos and pathos to suit the requirements of the particular case: "The content of... statements, the manner in which propositions will be expressed, the language, and images in casting the statements will be determined by the topical examination of the ethos and pathos of [a] particular speaker-auditor's situation" (Commentary I, 335n). Grimaldi convinced no one that this was the case; as Jakob Wisse has pointed out, Grimaldi's interpretation takes unacceptable hermeneutic liberties (27-28); nothing in the Rhetoric supports his view of the enthymeme as the central organizing principle of the work.Although we agree that Grimaldi was mistaken, we would like to argue that he was correct in seeing inferential processes as the key to the Rhetoric's conceptual unity. We would like to claim, however, that, contrary to Grimaldi's view, each of the three pisteis is inference-based, as is the canon of style. Moreover, the canon of arrangement, while not inference-based for Aristotle, plays a vital role in strengthening the patterns of inference that speakers prefer; in addition, it can be inference-based, as Perleman and Olbrechts-Tyteca have shown. So much conceptual unity seems to us consistent with Aristotle's definition of rhetoric; if such unity exists, it would mean that Aristotle was correct in calling rhetoric a tekhnê, which was, like dialectic or medicine, a unified body of knowledge (1.1.2-1354a1-14)We are not going to argue that the text as we have it is conceptually unified; obviously, no text that contains inconsistent views and serious ambiguities can be unified and there is little doubt that the Rhetoric contains such inconsistencies and ambiguities. With the aid of current scholarship, however, we intend to construct from the text a consistent theory of persuasion with inference as its base. In our construction, we will add nothing to Aristotle. But we will omit some passages--especially, a crucial one in which he seems clearly to spurn emotional and ethical means of persuasion (1.1.3-1354a16-45). We will also prefer some interpretations--especially an... (shrink)